Repressive inclusion

Repressive Tolerance

This essay examines the idea of tolerance in our advanced industrial society. The conclusion reached is that the realization of the objective of tolerance would call for intolerance toward prevailing policies, attitudes, opinions, and the extension of tolerance to policies, attitudes, and opinions which are outlawed or suppressed. In other words, today tolerance appears again as what it was in ...

Huntingtin Facilitates Polycomb Repressive Complex

LATS2 Positively Regulates Polycomb Repressive Complex 2

LATS2, a pivotal Ser/Thr kinase of the Hippo pathway, plays important roles in many biological processes. LATS2 also function in Hippo-independent pathway, including mitosis, DNA damage response and epithelial to mesenchymal transition. However, the physiological relevance and molecular basis of these LATS2 functions remain obscure. To understand novel functions of LATS2, we constructed a LATS2...

Chaperoning RNA Polymerase II through repressive chromatin.

The histone chaperone Spt6 is known to facilitate transcriptional elongation while preventing spurious initiation of transcription within the coding region of genes. A recent publication in The EMBO Journal (Wang et al, 2013) identifies an additional mechanism by which Spt6 promotes gene expression by demonstrating that it tethers the histone demethylase UTX/KDM6A to the elongating RNA Polymera...

Molecular architecture of polycomb repressive complexes

The polycomb group (PcG) proteins are a large and diverse family that epigenetically repress the transcription of key developmental genes. They form three broad groups of polycomb repressive complexes (PRCs) known as PRC1, PRC2 and Polycomb Repressive DeUBiquitinase, each of which modifies and/or remodels chromatin by distinct mechanisms that are tuned by having variable compositions of core an...